Grapefruit

GRAPEFRUIT

Grapefruit (Citrus paradisi) is a citrus fruit. It has been used for weight loss. It has also been used for other conditions, but with limited evidence.

Grapefruit is a source of vitamin C, fiber, potassium, pectin, and other nutrients. People use the fruit, oil from the peel, and extracts as medicine. Drug interactions with grapefruit juice are well documented. Before adding it to your diet, check with your healthcare provider if you take medications.

People commonly take grapefruit by mouth for weight loss, asthma, high cholesterol, cancer, and many other conditions, but there is no good scientific evidence to support these uses.

Uses & Effectiveness ?

We currently have no information for GRAPEFRUIT overview .

Side Effects

When taken by mouth: Grapefruit is commonly consumed as a food or juice. Grapefruit products are possibly safe when taken by mouth as a medicine. But it is possibly unsafe for postmenopausal adults to take grapefruit in large amounts.

If you take any medications, check with your healthcare provider before adding grapefruit to your diet or using it as a medicine. Grapefruit interacts with a long list of medications.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn't enough reliable information to know if grapefruit is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to normal food amounts.

A heart muscle disorder (cardiomyopathy): Drinking grapefruit juice might increase the risk for abnormal heart rhythm. People with this condition should consume grapefruit juice in moderation.

Hormone sensitive cancers and conditions: Drinking large amounts of grapefruit juice might increase hormone levels and therefore increase the risk of hormone sensitive conditions. People with hormone sensitive conditions should avoid grapefruit.

Irregular heartbeat: Eating large amounts of grapefruit or drinking grapefruit juice might worsen irregular heartbeat. Don't use grapefruit if you have this condition.

Postmenopausal adults: Postmenopausal adults should avoid drinking large amounts of grapefruit juice. It's been linked with an increased risk of breast cancer in these patients.

Interactions ?

Major Interaction

Do not take this combination

Artemether (Artenam, Paluther) interacts with GRAPEFRUIT

The body breaks down artemether (Artenam, Paluther) to get rid of it. Grapefruit juice can decrease how quickly the body breaks down artemether (Artenam, Paluther). Drinking grapefruit juice while taking artemether (Artenam, Paluther) might increase the effects and side effects of artemether (Artenam, Paluther). Do not drink grapefruit juice if you are taking artemether (Artenam, Paluther).

Buspirone (BuSpar) interacts with GRAPEFRUIT

Grapefruit juice might increase how much buspirone (BuSpar) the body absorbs. Drinking grapefruit juice while taking buspirone (BuSpar) might increase the effects and side effects of buspirone (BuSpar).

Carbamazepine (Tegretol) interacts with GRAPEFRUIT

Grapefruit juice might increase how much carbamazepine (Tegretol) the body absorbs. Drinking grapefruit juice while taking carbamazepine (Tegretol) might increase the effects and side effects of carbamazepine (Tegretol).

Carvedilol (Coreg) interacts with GRAPEFRUIT

The body breaks down carvedilol (Coreg) to get rid of it. Grapefruit juice seems to decrease how quickly the body breaks down carvedilol (Coreg). Drinking grapefruit juice while taking carvedilol (Coreg) might increase the effects and side effects of carvedilol (Coreg).

Cisapride (Propulsid) interacts with GRAPEFRUIT

Grapefruit juice might decrease how quickly the body gets rid of cisapride (Propulsid). Drinking grapefruit juice while taking cisapride (Propulsid) might increase the effects and side effects of cisapride (Propulsid).

Clomipramine (Anafranil) interacts with GRAPEFRUIT

The body breaks down clomipramine (Anafranil) to get rid of it. Grapefruit juice might decrease how quickly the body gets rid of clomipramine (Anafranil). Taking grapefruit juice along with clomipramine (Anafranil) might increase the effects and side effects of clomipramine (Anafranil).

Cyclosporine (Neoral, Sandimmune) interacts with GRAPEFRUIT

Grapefruit might increase how much cyclosporine (Neoral, Sandimmune) the body absorbs. Drinking grapefruit juice while taking cyclosporine (Neoral, Sandimmune) might increase the side effects of cyclosporine.

Dextromethorphan (Robitussin DM, and others) interacts with GRAPEFRUIT

The body breaks down dextromethorphan (Robitussin DM, others) to get rid of it. Grapefruit might decrease how quickly the body breaks down dextromethorphan (Robitussin DM, others). Drinking grapefruit juice while taking dextromethorphan (Robitussin DM, others) might increase the effects and side effects of dextromethorphan (Robitussin DM, others).

Estrogens interacts with GRAPEFRUIT

The body breaks down estrogens to get rid of them. Grapefruit juice seems to decrease how quickly the body breaks down estrogens and increase how much estrogen the body absorbs. Drinking grapefruit juice while taking estrogens might increase estrogen levels and side effects associated with estrogen such as breast cancer.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol (Climara, Vivelle, Estring), and others.

Etoposide (VePesid) interacts with GRAPEFRUIT

Grapefruit might decrease how much etoposide (VePesid) the body absorbs. Drinking grapefruit juice while taking etoposide (VePesid) might decrease the effectiveness of etoposide (VePesid).

Itraconazole (Sporanox) interacts with GRAPEFRUIT

Itraconazole (Sporanox) is used to treat fungal infections. Grapefruit juice might decrease how much itraconazole (Sporanox) the body absorbs. Drinking grapefruit juice while taking itraconazole (Sporanox) might decrease the effectiveness of Itraconazole (Sporanox). Do not drink grapefruit juice if you are taking Itraconazole (Sporanox).

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with GRAPEFRUIT

Some medications are changed and broken down by the liver.

Grapefruit juice might decrease how quickly the liver breaks down some medications. Drinking grapefruit juice while taking some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit, talk to your healthcare provider if you are taking any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

Medications for high blood pressure (Calcium channel blockers) interacts with GRAPEFRUIT

Grapefruit juice might increase how much medication for high blood pressure the body absorbs. Drinking grapefruit juice while taking some medications for high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.

Medications used for lowering cholesterol (Statins) interacts with GRAPEFRUIT

The body breaks down some medications used for lowering cholesterol to get rid of them. Grapefruit juice might decrease how quickly the body breaks down some medications used for lowering cholesterol. Drinking grapefruit juice while taking some medications used for lowering cholesterol might increase the effects and side effects of these medications.

Some medications used for high cholesterol include lovastatin (Mevacor), simvastatin (Zocor), atorvastatin (Lipitor), cerivastatin (Baycol), and others.

However, grapefruit juice doesn't seem to affect pravastatin (Pravachol).

Methylprednisolone interacts with GRAPEFRUIT

The body breaks down methylprednisolone to get rid of it. Grapefruit juice can decrease how quickly the body gets rid of methylprednisolone. Drinking grapefruit juice while taking methylprednisolone might increase the effects and side effects of methylprednisolone.

Praziquantel (Biltricide) interacts with GRAPEFRUIT

The body breaks down praziquantel (Biltricide) to get rid of it. Grapefruit juice can decrease how quickly the body breaks down praziquantel (Biltricide). Drinking grapefruit juice while taking praziquantel (Biltricide) might increase the effects and side effects of praziquantel (Biltricide).

Quinidine interacts with GRAPEFRUIT

The body breaks down quinidine to get rid of it. Grapefruit juice might decrease how fast the body gets rid of quinidine. Drinking grapefruit juice while taking quinidine might increase the chance of side effects.

Scopolamine (Transderm Scop) interacts with GRAPEFRUIT

The body breaks down scopolamine to get rid of it. Grapefruit juice can decrease how fast the body breaks down scopolamine. Drinking grapefruit juice while taking scopolamine might increase the effects and side effects of scopolamine.

Sedative medications (Benzodiazepines) interacts with GRAPEFRUIT

Sedative medications can cause sleepiness and drowsiness. Grapefruit juice can decrease how quickly the body breaks down some medications. Drinking grapefruit juice while taking some sedative medications can increase the effects and side effects of some sedative medications.

Some sedative medications that might interact with grapefruit juice include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others.

Sildenafil (Viagra) interacts with GRAPEFRUIT

The body breaks down sildenafil (Viagra) to get rid of it. Grapefruit can decrease how quickly the body breaks down sildenafil (Viagra). Drinking grapefruit juice while taking sildenafil (Viagra) can increase the effects and side effects of sildenafil.

Terfenadine (Seldane) interacts with GRAPEFRUIT

Grapefruit can increase how much terfenadine (Seldane) that the body absorbs. Drinking grapefruit juice while taking terfenadine (Seldane) might increase the effects and side effects of terfenadine (Seldane).

Moderate Interaction

Be cautious with this combination

Caffeine interacts with GRAPEFRUIT

The body breaks down caffeine to get rid of it. Grapefruit might decease how quickly the body gets rid of caffeine. Drinking grapefruit while taking caffeine might increase the side effects of caffeine including jitteriness, headache, and a fast heartbeat.

Erythromycin interacts with GRAPEFRUIT

The body breaks down erythromycin to get rid of it. Grapefruit can decrease how quickly the body gets rid of erythromycin. Taking grapefruit juice along with erythromycin might increase the effects and side effects of erythromycin.

Fexofenadine (Allegra) interacts with GRAPEFRUIT

Grapefruit might decrease how much fexofenadine (Allegra) the body absorbs. Drinking grapefruit juice while taking fexofenadine (Allegra) might decrease the effectiveness of fexofenadine (Allegra).

Losartan (Cozaar) interacts with GRAPEFRUIT

The liver activates losartan (Cozaar) to make it work. Grapefruit juice might decrease how quickly the body activates losartan (Cozaar). Drinking grapefruit juice while taking losartan (Cozaar) might decrease the effectiveness of losartan.

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with GRAPEFRUIT

Some medications are changed and broken down by the liver.

Grapefruit juice might decrease how quickly the liver breaks down some medications. Taking grapefruit juice along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit juice talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, others), verapamil (Calan, Isoptin, others), and others.

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with GRAPEFRUIT

Some medications are changed and broken down by the liver.

Grapefruit juice might decrease how quickly the liver breaks down some medications. Taking grapefruit juice along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit juice talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene); celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others.

Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with GRAPEFRUIT

Some medications are changed and broken down by the liver.

Grapefruit juice might decrease how quickly the liver breaks down some medications. Taking grapefruit juice along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking grapefruit juice talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include omeprazole (Prilosec), lansoprazole (Prevacid), and pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); and others.

Saquinavir (Fortovase, Invirase) interacts with GRAPEFRUIT

Drinking grapefruit juice can increase how much saquinavir (Fortovase, Invirase) the body absorbs. Drinking grapefruit juice while taking saquinavir (Fortovase, Invirase) might increase the effects and side effects of saquinavir.

Theophylline interacts with GRAPEFRUIT

Drinking grapefruit juice might decrease the effects of theophylline. There's not enough information to know if this is a big concern.

Warfarin (Coumadin) interacts with GRAPEFRUIT

Warfarin (Coumadin) is used to slow blood clotting. Drinking grapefruit juice might increase the effects of warfarin (Coumadin) and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.

Dosing

Grapefruit and grapefruit juice are commonly consumed as part of the diet. The pectin, extracts, and freeze-dried whole fruit are also used as medicine. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Keep in mind that drug interactions with grapefruit juice are well documented. Before adding it to your diet, check with your healthcare provider if you take medications.

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